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The British Journal of Psychiatry 137: 458-468 (1980)
© 1980 The Royal College of Psychiatrists

Some clinical and metabolic aspects of propranolol in chronic schizophrenia

DJ King, SN Turkson, J Liddle and CD Kinney

No benefit attributable to propranolol (1000 mg/day) could be detected in a trial lasting at least 22 weeks, 6 weeks of which was double-blind placebo-controlled, in 5 chronic schizophrenic patients. The mean propranolol CSF/plasma ration was 0.08, and there was good agreement between CSF and free plasma propranolol levels. Basal plasma prolactin was slightly but insignificantly reduced by propranolol, and metoclopramide-stimulated prolactin release was unaffected. Propranolol was associated with a significant temporary increase in HVA, a non- significant rise in 5-HIAA and a significant decrease in MHPG, in the lumbar cerebrospinal fluid of 4 patients.


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J.F.W. Deakin, M.D.C. Simpson, P. Slater, and J.S.E. Hellewell
Familial and developmental abnormalities of frontal lobe function and neurochemistry in schizophrenia
J Psychopharmacol, January 1, 1997; 11(2): 133 - 142.
[Abstract] [PDF]


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Copyright © 1980 The Royal College of Psychiatrists.