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The British Journal of Psychiatry 137: 522-529 (1980)
© 1980 The Royal College of Psychiatrists

Controlled trial of sulpiride in chronic schizophrenic patients

JG Edwards, JR Alexander, MS Alexander, A Gordon and T Zutchi

In a double-blind comparative trial of sulpiride (600-1,800 mg/day) and trifluoperazine (15-45 mg/day) in 38 chronic schizophrenic patients, ratings of therapeutic results and unwanted effects were made at two- weekly interviews during the six weeks treatment period. The results show that sulpiride has neuroleptic properties and a spectrum of therapeutic activity similar to that of trifluoperazine. There was an association between plasma sulpiride levels and therapeutic response after four weeks' treatment.


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Home page
 Arch Gen PsychiatryHome page
D. V. Jeste and R. Jed Wyatt
Therapeutic Strategies Against Tardive Dyskinesia: Two Decades of Experience
Arch Gen Psychiatry, July 1, 1982; 39(7): 803 - 816.
[Abstract] [PDF]


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Copyright © 1980 The Royal College of Psychiatrists.