BJP College Seminars Series
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Checkley, S. A.
Right arrow Articles by Dawling, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Checkley, S. A.
Right arrow Articles by Dawling, S.

The British Journal of Psychiatry 138: 248-251 (1981)
© 1981 The Royal College of Psychiatrists

A pilot study of the mechanism of action of desipramine

SA Checkley, AP Slade, E Shur and S Dawling

To test the hypothesis the desipramine alters alpha adrenoceptor function in depressed patients, the effects of clonidine upon growth hormone sedation and blood pressure have been measured in depressed patients before and after treatment with desipramine. After three weeks of treatment the hypotensive and sedative effects of clonidine were inhibited in all patients even though plasma desipramine concentrations at this time varied from 42 to 560 micrograms/l. Growth hormone responses to clonidine were enhanced in five of the six patients but this effect was not statistically significant. These findings are consistent with the hypothesis that in these patients desipramine altered alpha adrenoceptor function: other explanation are discussed.


This article has been cited by other articles:


Home page
 J PsychopharmacolHome page
D. J. Nutt and P. Glue
Imipramine in panic disorder. 2. Effects on {alpha}2-adrenoceptor function
J Psychopharmacol, January 1, 1991; 5(2): 135 - 141.
[Abstract] [PDF]

Home page
 J PsychopharmacolHome page
P. Glue, D. Nutt, and P. Glue
Clonidine challenge testing of alpha-2-adrenoceptor function in man: the effects of mental illness and psychotropic medication
J Psychopharmacol, January 1, 1988; 2(3-4): 119 - 137.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1981 The Royal College of Psychiatrists.