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The British Journal of Psychiatry 138: 252-256 (1981)
© 1981 The Royal College of Psychiatrists

Lithium induces rapid relief of depression in tricyclic antidepressant drug non-responders

C De Montigny, F Grunberg, A Mayer and JP Deschenes

Eight patients suffering from a major unipolar depression and having field to respond to treatment for three weeks or more with tricyclic antidepressants were given lithium. All eight patients experienced a remarkable relief of their depression within 48 hours. This rapid antidepressant effect of lithium in "treatment-resistant' patients might be due to the enhancement of the efficacy of the central serotoninergic system, unveiling the tricyclic antidepressant-induced sensitization of the serotoninergic postsynaptic receptors.


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