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The British Journal of Psychiatry 139: 105-111 (1981)
© 1981 The Royal College of Psychiatrists

Propranolol in schizophrenia. I. Comparison of propranolol, chlorpromazine and placebo

M Peet, MS Bethell, A Coates, AK Khamnee, P Hall, SJ Cooper, DJ King and RA Yates

Fifty-three hospitalized chronic schizophrenic patients were treated with either propranolol, chlorpromazine or placebo in a double-blind randomized trials for up to three months. Propranolol in a usual dose of 640 mg/day, produced marked cardiovascular effects but no improvement in schizophrenic symptomatology relative to placebo. The effects of chlorpromazine were small and inconsistent.


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J.F.W. Deakin, M.D.C. Simpson, P. Slater, and J.S.E. Hellewell
Familial and developmental abnormalities of frontal lobe function and neurochemistry in schizophrenia
J Psychopharmacol, January 1, 1997; 11(2): 133 - 142.
[Abstract] [PDF]


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Copyright © 1981 The Royal College of Psychiatrists.