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The British Journal of Psychiatry 139: 513-518 (1981)
© 1981 The Royal College of Psychiatrists

Quantitative determination of immunoglobulins in CSF and plasma of chronic schizophrenic patients

LE Delisi, DR Weinberger, S Potkin, LM Neckers, DJ Shiling and RJ Wyatt

Immunoglobulins, IgG, IgA and IgM were quantified in cerebrospinal fluid (CSF) and plasma from chronic schizophrenic patients and controls using an immunofluorescent antibody technique. A generalized reduction in immunoglobulin levels was observed in the schizophrenic patients compared with controls. While this study supports other reports of abnormal immune functioning in schizophrenia, it failed to replicate previous findings of elevations in CSF IgG and elevations in serum IgA. The aetiology and significance of these findings are hypothesized but remain elusive.




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1981 The Royal College of Psychiatrists.