The British Journal of Psychiatry 139: 553-557 (1981)
© 1981 The Royal College of Psychiatrists
Functional tests of the corpus callosum in schizophrenia
GH Jones and JJ Miller
The corpus callosum, a cerebral commissure of 200,000,000 fibres, is
thickened in chronic schizophrenia and several neuropsychological and
neurophysiological techniques have suggested poor links between the two
cerebral hemispheres. The interhemispheric conduction time across the
corpus callosum, measured in 12 schizophrenics, using the
ipsilateral/contralateral latency differences of the early somatosensory
evoked response, was found to be effectively zero. It is suggested that
schizophrenia is a split-brain condition akin to agenesis of the corpus
callosum, unrecognized through the use of compensatory ipsilateral sensory
pathways.