| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Psychiatric Bulletin | Advances in Psychiatric Treatment | All RCPsych Journals |
|
|
|
||||||||||
|
||||||||||||
The British Journal of Psychiatry 140: 1-6 (1982)
© 1982 The Royal College of Psychiatrists
P McGuffin, A Reveley and A Holland
In contrast to all previous reports of psychoses in genetically identical siblings, identical triplets aged 28 were discordant by major Kraepelinian type of psychosis. Two of them had been diagnosed schizophrenic while the third was diagnosed manic depressive. Re- evaluation of their illnesses using standardized methods and diagnosis by blind raters suggested that the discordance was not due to simple misdiagnosis or different diagnostic bias between psychiatrists. These triplets illustrate some of the shortcomings of a strictly applied Kraepelinian dichotomy and show that a genetic perspective is important in attempting to resolve the classificatory problems of atypical psychoses.
This article has been cited by other articles:
|
|
 |
|
  K. M. Prasad and M. S. Keshavan Structural Cerebral Variations as Useful Endophenotypes in Schizophrenia: Do They Help Construct "Extended Endophenotypes"? Schizophr Bull, July 1, 2008; 34(4): 774 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Greene The Kraepelinian dichotomy: the twin pillars crumbling? History of Psychiatry, September 1, 2007; 18(71 Pt 3): 361 - 379. [Abstract] [PDF]
|
|
|
|
|
|
M. J. Owen, N. Craddock, and A. Jablensky The Genetic Deconstruction of Psychosis Schizophr Bull, July 1, 2007; 33(4): 905 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Abou Jamra, C. Schmael, S. Cichon, M. Rietschel, J. Schumacher, and M. M. Nothen Genes and Schizophrenia: The G72/G30 Gene Locus in Psychiatric Disorders: A Challenge to Diagnostic Boundaries? Schizophr Bull, October 1, 2006; 32(4): 599 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Craddock, M. C O'Donovan, and M. J Owen Genes for Schizophrenia and Bipolar Disorder? Implications for Psychiatric Nosology Schizophr Bull, January 1, 2006; 32(1): 9 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Green, R. Raybould, S. Macgregor, K. Gordon-Smith, J. Heron, S. Hyde, D. Grozeva, M. Hamshere, N. Williams, M. J. Owen, et al. Operation of the Schizophrenia Susceptibility Gene, Neuregulin 1, Across Traditional Diagnostic Boundaries to Increase Risk for Bipolar Disorder Arch Gen Psychiatry, June 1, 2005; 62(6): 642 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Craddock, M C O'Donovan, and M J Owen The genetics of schizophrenia and bipolar disorder: dissecting psychosis J. Med. Genet., March 1, 2005; 42(3): 193 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Cardno, F. V. Rijsdijk, P. C. Sham, R. M. Murray, and P. McGuffin A Twin Study of Genetic Relationships Between Psychotic Symptoms Am J Psychiatry, April 1, 2002; 159(4): 539 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Craddock and I. Jones Genetics of bipolar disorder J. Med. Genet., August 1, 1999; 36(8): 585 - 594. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. M. Murray and A. Foerster Schizophrenia: is the concept disintegrating? J Psychopharmacol, January 1, 1987; 1(3): 133 - 139. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Psychiatric Bulletin | Advances in Psychiatric Treatment | All RCPsych Journals |
