The British Journal of Psychiatry 140: 188-191 (1982)
© 1982 The Royal College of Psychiatrists
Unusual mood stability in patients taking lithium
MF Folstein, JR DePaulo Jr and K Trepp
The Visual Analogue Mood Scale (VAMS) was completed for 30 consecutive days
by 124 psychiatric patients and 36 non-patients control subjects. The 64
euthymic manic-depressive patients on chronic lithium therapy had similar
mean mood ratings to the non-patient controls, but had lower mood
variability as measured either by standard deviation of the mood rating or
by a measure of the mean successive differences between consecutive mood
ratings (delta squared). This unusual mood stability appears to be an
effect on lithium therapy. This study thus offers some empirical support
for the 'mood stabilizer' psychological model of lithium's effects in
patients. It is also noted that this effect may be perceived in well
patients as an undesirable effect of lithium treatment.