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The British Journal of Psychiatry 140: 274-279 (1982)
© 1982 The Royal College of Psychiatrists

Plasma prolactin and growth hormone levels in manic patients treated with pimozide

JC Cookson, T Silverstone and L Rees

During two weeks' treatment of 11 manic patients with pimozide there was close correspondence between the timecourse of improvement in clinical ratings and the rise in plasma prolactin between the second and fourteenth day. There were no significant differences in growth hormone levels during the manic episodes compared to recovery. These findings are discussed in relation to the role of dopamine in the release of prolactin and growth hormone, and in the pathogenesis of mania.


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L. N. Yatham, P. F. Liddle, R. W. Lam, I-S. Shiah, C. Lane, A. J. Stoessl, V. Sossi, and T. J. Ruth
PET Study of the Effects of Valproate on Dopamine D2 Receptors in Neuroleptic- and Mood-Stabilizer-Naive Patients With Nonpsychotic Mania
Am J Psychiatry, October 1, 2002; 159(10): 1718 - 1723.
[Abstract] [Full Text] [PDF]


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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1982 The Royal College of Psychiatrists.