The British Journal of Psychiatry 140: 464-469 (1982)
© 1982 The Royal College of Psychiatrists
Fluctuations of free choline levels in plasma of Alzheimer patients receiving lecithin: preliminary observations
P Chuaqui and R Levy
Plasmas of 12 patients currently taking part in a double-blind trial of
lecithin in senile or presenile dementia of Alzheimer type were analysed
for plasma choline levels at fixed intervals during lecithin treatment. The
values were not maintained at a constant level and showed a decline after
one or two months of treatment, often followed by a subsequent rise.
Possible explanations for this observation are given, and its significance
to the treatment of dementia discussed.