The British Journal of Psychiatry 140: 484-490 (1982)
© 1982 The Royal College of Psychiatrists
Does tryptophan potentiate clomipramine in the treatment of agoraphobic and social phobic patients?
JC Pecknold, DJ McClure, L Appeltauer, T Allan and L Wrzesinski
A 10 week double blind study of 24 agoraphobics and 16 social phobics all
on clomipramine compared the effect of adding tryptophan or placebo.
Tryptophan did not potentiate the beneficial effect of clomipramine on
phobic avoidance, phobic fears or the incidence of panic attacks. Neither
was the presence of depression a factor of outcome.