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The British Journal of Psychiatry 140: 503-507 (1982)
© 1982 The Royal College of Psychiatrists

Haloperidol-induced changes in blink rates correlate with changes in BPRS score

CN Karson, LB Bigelow, JE Kleinman, DR Weinberger and RJ Wyatt

Spontaneous eye blink rates, psychiatric symptoms and response to neuroleptic medication may all be mediated by dopamine. Fixed doses of haloperidol, a dopamine blocking agent, were administered for six weeks to 17 chronic schizophrenic patients who had been previously withdrawn from all medications. The change in blink rates caused by haloperidol corresponded to a change in the thought disturbance syndrome which measures positive symptoms (r = .48, P less than .05). The relationship was particularly clear in patients with normal cerebral ventricles (r = .74, P less than .01).


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J. van der Post, P. P. de Waal, M. L. de Kam, A. F. Cohen, and J. M. A. van Gerven
No evidence of the usefulness of eye blinking as a marker for central dopaminergic activity
J Psychopharmacol, March 1, 2004; 18(1): 109 - 114.
[Abstract] [PDF]


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Copyright © 1982 The Royal College of Psychiatrists.