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The British Journal of Psychiatry 140: 611-614 (1982)
© 1982 The Royal College of Psychiatrists

Demethylation of C14 2,3,4-trimethoxyphenylethylamine in schizophrenics before and after L-methionine loading

FT Antun and R Kurkjian

Demethylation was compared in acute and chronic schizophrenics and in non-schizophrenics by the administration of C14 labelled 2,3,4- trimethoxyphenylethylamine (TMPEA). The results did not show a significant difference in the urinary levels of the monodemethylated catabolites of TMPEA among any groups of patients. However, there was a significant decrease in demethylation in untreated chronic schizophrenics after ten days of L-methionine orally, whereas the non- schizophrenic group similarly given methionine did not change. This suggests the possibility of a biological weakness in schizophrenia.




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1982 The Royal College of Psychiatrists.