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The British Journal of Psychiatry 141: 243-248 (1982)
© 1982 The Royal College of Psychiatrists

Influence of acetylator phenotype on antidepressant effects of phenelzine

ES Paykel, PS West, PR Rowan and RR Parker

Acetylator phenotype, determined by blood levels after sulphadimidine, was related to outcome in a controlled trial of phenelzine in patients with depression and mixed anxiety depression. Slow acetylators showed more improvement and greater phenelzine-placebo differences than did fast acetylators, at two, four and six weeks. A tendency towards faster acetylation was observed in subjects with previous increased alcohol intake. Acetylator phenotype was not related to other symptom, diagnostic or history data.


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Copyright © 1982 The Royal College of Psychiatrists.