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The British Journal of Psychiatry 142: 391-397 (1983)
© 1983 The Royal College of Psychiatrists

Subjective side-effects of amitriptyline and lithium in affective disorders

MT Abou-Saleh and A Coppen

The prevalence of subjective side-effects was studied in 258 control subjects, 65 drug-free depressive in-patients and 94 lithium-treated out-patients. It was shown that drug-free depressives reported more side-effects than both control subjects and lithium-treated patients. Side-effects were studied during amitriptyline therapy. Depressed patients on no medication complained of only slightly fewer side- effects than when they had received amitriptyline. There was a significant positive correlation of Hamilton depression scores and side- effects scores at baseline. Side-effects and affective morbidity over two years were investigated in 94 patients with recurrent affective disorders on long-term lithium therapy. Psychological variables were also investigated in 74 of these patients. Subjective side-effects reported by lithium-treated patients including those specific to lithium were related to their affective morbidity and personality variables. Patients on lithium complained significantly less of headache and unilateral headache than controls.




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1983 The Royal College of Psychiatrists.