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The British Journal of Psychiatry 144: 341-348 (1984)
© 1984 The Royal College of Psychiatrists

Clinical effects of apomorphine in schizophrenia

IN Ferrier, EC Johnstone and TJ Crow

There have been reports that low doses of the dopamine-agonist apomorphine, which may inhibit dopamine neurotransmission, are of therapeutic benefit in schizophrenia. We conducted a placebo-controlled study of acute and chronic schizophrenics in which videotaped interviews were blindly rated. No specific therapeutic effect was demonstrated for apomorphine other than a reduction in anxiety in acute schizophrenics. Furthermore, there was no difference in the frequency of side-effects of apomorphine between schizophrenic patients and controls, and no specific effect of apomorphine on blink-rates. These findings emphasize the importance of placebo-controlled studies in schizophrenia research.




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1984 The Royal College of Psychiatrists.