This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Coryell, W.
Right arrow Articles by Keller, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Coryell, W.
Right arrow Articles by Keller, M.

The British Journal of Psychiatry 145: 49-54 (1984)
© 1984 The Royal College of Psychiatrists

A family study of bipolar II disorder

W Coryell, J Endicott, T Reich, N Andreasen and M Keller

Professional raters who were blind to proband diagnosis used the schedule for affective disorders and schizophrenia (SADS-L) and the Research Diagnostic Criteria (RDC) to evaluate 1,210 first-degree relatives of 327 probands with primary major depression, participating in the family sub-study of the NIMH Collaborative Study of the Affective Disorders--Clinical Branch. Bipolar II probands were significantly more likely to have bipolar II relatives than were non- bipolar or bipolar I probands. Bipolar II probands were slightly more likely than non-bipolar probands and slightly less likely than bipolar I probands to have relatives with bipolar I illness. Similar patterns have emerged in two other recently reported family studies of bipolar II illness. Taken together, these data suggest heterogeneity among patients with bipolar II depression. Some appear to be genotypes for bipolar I illness, while a small proportion may be genotypes for non- bipolar illness. A third group, of undetermined size, may breed true.


This article has been cited by other articles:


Home page
 Arch Gen PsychiatryHome page
S. G. Simpson, F. J. McMahon, M. G. McInnis, D. F. MacKinnon, D. Edwin, S. E. Folstein, and J. R. DePaulo
Diagnostic Reliability of Bipolar II Disorder
Arch Gen Psychiatry, August 1, 2002; 59(8): 736 - 740.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
I. N. FERRIER, I. C. MacMILLAN, and A. H. YOUNG
The search for the wandering thymostat: a review of some developments in bipolar disorder research
The British Journal of Psychiatry, June 1, 2001; 178 (41): s103 - s106.
[Full Text] [PDF]

Home page
 Psychiatr. Serv.Home page
G. M. MacQueen and L. T. Young
Bipolar II Disorder: Symptoms, Course, and Response to Treatment
Psychiatr Serv, March 1, 2001; 52(3): 358 - 361.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
G. Winokur, W. Coryell, M. Keller, J. Endicott, and A. Leon
A Family Study of Manic-Depressive (Bipolar I) Disease: Is It a Distinct Illness Separable From Primary Unipolar Depression?
Arch Gen Psychiatry, May 1, 1995; 52(5): 367 - 373.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
H. S. Akiskal, J. D. Maser, P. J. Zeller, J. Endicott, W. Coryell, M. Keller, M. Warshaw, P. Clayton, and F. Goodwin
Switching From 'Unipolar' to Bipolar II: An 11-Year Prospective Study of Clinical and Temperamental Predictors in 559 Patients
Arch Gen Psychiatry, February 1, 1995; 52(2): 114 - 123.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
G. Winokur, W. Coryell, M. Keller, J. Endicott, and H. Akiskal
A Prospective Follow-up of Patients With Bipolar and Primary Unipolar Affective Disorder
Arch Gen Psychiatry, June 1, 1993; 50(6): 457 - 465.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
D. W. Black, R. Noyes Jr, R. B. Goldstein, and N. Blum
A Family Study of Obsessive-Compulsive Disorder
Arch Gen Psychiatry, May 1, 1992; 49(5): 362 - 368.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
W. Coryell and M. Zimmerman
The Heritability of Schizophrenia and Schizoaffective Disorder: A Family Study
Arch Gen Psychiatry, April 1, 1988; 45(4): 323 - 327.
[Abstract] [PDF]