The British Journal of Psychiatry 145: 294-299 (1984)
© 1984 The Royal College of Psychiatrists
Zetidoline, a new antipsychotic. First controlled trial in acute schizophrenia
T Silverstone, S Levine, HL Freeman and A Dubini
Zetidoline (ZTD), a compound chemically unrelated to any available
antipsychotic, with selective dopamine receptor-blocking properties, was
compared with haloperidol (HLP) in a double-blind study on 56 in- patients
who had either first episodes or acute relapses of schizophrenia. ZTD was
found to be safe, as effective as HLP, and to produce significantly fewer
extrapyramidal side-effects (EPS).