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The British Journal of Psychiatry 148: 655-657 (1986)
© 1986 The Royal College of Psychiatrists

Prevalence of the fragile X syndrome in an institution for the mentally handicapped

DA Primrose, R el-Matmati, E Boyd, C Gosden and M Newton

In an investigation to find the prevalence of the fragile X (Martin Bell) syndrome in a mental handicap hospital, chromosomal investigations were carried out in 196 males selected out of a total of 512, and also in 20 female patients who were related to some of the selected males. Fragile X cells were found in 41 of the males and two of the females; in 21 of the males it was associated with macro- orchidism. The overall prevalence in the hospital for males (8.0%) ranks this syndrome next in importance to Down's syndrome as a known cause for mental handicap.




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1986 The Royal College of Psychiatrists.