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The British Journal of Psychiatry 150: 208-212 (1987)
© 1987 The Royal College of Psychiatrists

CSF neuropeptides in euthymic bipolar patients and controls

WH Berrettini, JI Nurnberger Jr, RL Zerbe, PW Gold, GP Chrousos and T Tomai
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20205.

Levels of vasopressin, somatostatin, neurotensin, vasoactive intestinal peptide, corticotrophin-releasing factor and adrenocorticotrophin in CSF were determined in lithium-treated and unmedicated euthymic bipolar patients and controls, in a search for a trait marker in affective disorder. No group differences in levels of these peptides were found. Highly significant positive correlations were found among these peptides (with the exception of neurotensin), suggesting that their presence in CSF is functionally significant, as opposed to the result of random diffusion from the interstitial space of the brain.


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Copyright © 1987 The Royal College of Psychiatrists.