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The British Journal of Psychiatry 152: 122-126 (1988)
© 1988 The Royal College of Psychiatrists

Urinary catecholamine metabolite and tribulin output during lactate infusion

A Clow, V Glover, MW Weg, PL Walker, DV Sheehan, DB Carr and M Sandler
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Hospital, London.

Urinary output of homovanillic acid and 4-hydroxy-3-methoxymandelic acid was decreased both in patients with panic attacks and in normal controls during lactate infusion, whereas that of tribulin (an endogenous monoamine oxidase inhibitor and benzodiazepine receptor binding inhibitor) was increased. There was no change in urinary excretion of any of these compounds during saline infusion. These findings provide further evidence of a link between tribulin output and stress and anxiety in man and point to its possible in vivo action as a monoamine oxidase inhibitor.




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1988 The Royal College of Psychiatrists.