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The British Journal of Psychiatry 152: 59-63 (1988)
© 1988 The Royal College of Psychiatrists

The effect of electroconvulsive therapy on CSF amine metabolites in schizophrenic patients

SJ Cooper, W Leahey, DF Green and DJ King
Holywell Hospital, Belfast.

The effects of a series of six ECT treatments were observed on the CSF concentrations of HVA, MHPG, and 5-HIAA in 12 patients suffering from schizophrenia. Four patients were previously neuroleptic drug-free, and eight had received only oral neuroleptic drugs at the same dose for more than 4 weeks. A significant increase in the concentration of HVA was observed after the first ECT treatment but not after the final treatment. No significant changes were observed in the concentrations of MHPG and 5-HIAA. The patients improved clinically, and the results suggest that ECT has important effects on dopaminergic systems.


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Copyright © 1988 The Royal College of Psychiatrists.