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The British Journal of Psychiatry 152: 324-329 (1988)
© 1988 The Royal College of Psychiatrists

Partly dominant transmission of schizophrenia in Iceland

JL Karlsson
Institute of Genetics, Reykjavik, Iceland.

Voluminous data on the familial distribution of schizophrenia in Iceland were evaluated in terms of a partly dominant genetic mechanism. The risks were found in most instances to be proportional to the probability of harbouring the proposed gene, but penetrance rates, which generally are around 25%, appear to be elevated when additional risk factors are present. This occurs in individuals with multiple ill relatives, in offspring of two schizophrenic people, or in monozygotic co-twins. Excessive risks also occur in families with unusually severe disease.


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J. L. KARLSSON
Psychosis and academic performance
The British Journal of Psychiatry, April 1, 2004; 184(4): 327 - 329.
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