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The British Journal of Psychiatry 152: 560-562 (1988)
© 1988 The Royal College of Psychiatrists

A linkage study of primary affective disorder

B Waters, D Sengar, I Marchenko, G Rock, Y Lapierre, CJ Forster-Gibson and NE Simpson
Department of Child and Adolescent Psychiatry, Prince of Wales Hospital, Randwick, New South Wales, Australia.

Marker loci in 113 members of nine unrelated multiplex families identified by a bipolar proband were tested for linkages with primary affective disorder. Linkage was excluded between the disease locus (assuming that it was a single autosomal dominant gene) and the HLA loci at a recombination fraction of 0.2, the ABO, Rh, and Lu loci at almost 0.05 and the Fy and P loci at 0.001.




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1988 The Royal College of Psychiatrists.