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The British Journal of Psychiatry 153: 208-213 (1988)
© 1988 The Royal College of Psychiatrists

A clinical trial of the efficacy and acceptability of D-fenfluramine in the treatment of neuroleptic-induced obesity

E Goodall, C Oxtoby, R Richards, G Watkinson, D Brown and T Silverstone
Academic Unit of Human Psychopharmacology, Medical College, St Bartholomew's Hospital.

Twenty-nine overweight schizophrenic patients maintained on depot neuroleptic injections who wished to lose weight took part in a double- blind, placebo-controlled trial of 30 mg D-fenfluramine. All subjects received dietary advice. Sixteen patients completed the 12-week trial. Rate of weight loss was significantly greater in those taking D- fenfluramine. Side-effects were reported, but no deterioration in mental state was noted.


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Copyright © 1988 The Royal College of Psychiatrists.