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The British Journal of Psychiatry 153: 232-235 (1988)
© 1988 The Royal College of Psychiatrists

Premenstrual syndrome. A double-blind cross-over study of treatment with dydrogesterone and placebo

GA Sampson, PR Heathcote, J Wordsworth, P Prescott and A Hodgson
Whiteley Wood Clinic, Sheffield.

A double-blind, cross-over, placebo-controlled study of dydrogesterone (10 mg b.d.) in the treatment of premenstrual syndrome is described. Two groups of women were studied: secondarily referred hospital clinic patients, and self-referred patients. Only one-third of patients screened completed the study. All patients showed significant improvements in symptom scores during the course of the study, the only significant difference between placebo- and dydrogesterone-treated patients being an increase in frequency of breast tenderness and a decrease in pain with menstrual bleeding in the latter.


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K. Wyatt, P. Dimmock, P. Jones, M. Obhrai, and S. O'Brien
Efficacy of progesterone and progestogens in management of premenstrual syndrome: systematic review
BMJ, October 6, 2001; 323(7316): 776 - 776.
[Abstract] [Full Text] [PDF]


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Copyright © 1988 The Royal College of Psychiatrists.