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The British Journal of Psychiatry 153: 376-381 (1988)
© 1988 The Royal College of Psychiatrists

The expression of schizophrenia, affective disorder and vulnerability to tardive dyskinesia in an extensive pedigree

JL Waddington and HA Youssef
Royal College of Surgeons, St Stephen's Green, Dublin, Ireland.

The demography, psychiatric morbidity, and motor consequences of long- term neuroleptic treatment in the 14 children born to a father with a family history of chronic psychiatric illness and a mother with a late- onset affective disorder resulting in suicide are documented. Twelve siblings lived to adulthood, nine of whom were admitted to a psychiatric hospital in their second or third decade, and required continuous in-patient care; five remaining in hospital, with long-term exposure to neuroleptics, had chronic, deteriorating, schizophrenic illness and emergence of movement disorder. Two siblings showed no evidence of psychosis but developed a late-onset affective disorder. The implications for the issues of homotypia, vulnerability to involuntary movements, and interaction with affective disorder are discussed.


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Copyright © 1988 The Royal College of Psychiatrists.