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The British Journal of Psychiatry 153: 382-384 (1988)
© 1988 The Royal College of Psychiatrists

Plasma levels of fluphenazine decanoate. Effects of site of injection, massage and muscle activity

SD Soni, D Wiles, AA Schiff and JS Bamrah
Psychiatric Research Department, Salford Health Authority, Prestwich Hospital, Manchester.

Depot neuroleptics are now commonly used for maintenance therapy of schizophrenia. Their physicochemical composition makes them ideal for such use because they are long-acting and show stable blood levels for prolonged periods. Their absorption from the site of injection may, however, be affected by local muscle factors. This paper describes three such factors in relation to fluphenazine decanoate: varying the site of injection; massage of the injection site; and effects of muscular exercise. Our results suggest that fluphenazine pharmacokinetics are not significantly affected by any of these factors.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1988 The Royal College of Psychiatrists.