BJP Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Crow, T. J.
Right arrow Articles by Johnstone, E. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Crow, T. J.
Right arrow Articles by Johnstone, E. C.

The British Journal of Psychiatry 155: 92-97 (1989)
© 1989 The Royal College of Psychiatrists

Concordance by sex in sibling pairs with schizophrenia is paternally inherited. Evidence for a pseudoautosomal locus

TJ Crow, LE DeLisi and EC Johnstone
Division of Psychiatry, Northwick Park Hospital, Harrow.

The hypothesis that the gene for schizophrenia is located in the pseudoautosomal region of the sex chromosomes predicts that same-sex concordance will occur in paternally rather than maternally derived pairs. In 120 families that included at least one sibling pair with schizophrenia, affected members were significantly more likely to be of the same sex when there was a history of illness on the paternal than on the maternal side, the difference remaining significant when parent of origin was assessed by three different methods. The finding is as predicted by the pseudoautosomal hypothesis: therefore a search for the gene should be focused on this small (three megabase) region of the genome. The ratio of same to mixed sex pairs in paternally-derived cases (approximately 3:1) suggests the gene is located in the centromeric one-third of the pseudoautosomal region.


This article has been cited by other articles:


Home page
 Am. J. PsychiatryHome page
T. J. Crow
How and Why Genetic Linkage Has Not Solved the Problem of Psychosis: Review and Hypothesis
Am J Psychiatry, January 1, 2007; 164(1): 13 - 21.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
L. E. DeLisi, S. H. Shaw, T. J. Crow, G. Shields, A. B. Smith, V. W. Larach, N. Wellman, J. Loftus, B. Nanthakumar, K. Razi, et al.
A Genome-Wide Scan for Linkage to Chromosomal Regions in 382 Sibling Pairs With Schizophrenia or Schizoaffective Disorder
Am J Psychiatry, May 1, 2002; 159(5): 803 - 812.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
D. Lichtermann, I. Hovatta, J. D. Terwilliger, L. Peltonen, and J. Lönnqvist
Concordance for Sex and the Pseudoautosomal Gene Hypothesis Revisited: No Evidence of Increased Sex Concordance in a Nationwide Finnish Sample of Siblings With Paternally Derived Schizophrenia
Am J Psychiatry, October 1, 1998; 155(10): 1365 - 1375.
[Abstract] [Full Text]

Home page
 J PsychopharmacolHome page
T.J. Crow
Sexual selection as the mechanism of evolution of Machiavellian intelligence: a Darwinian theory of the origins of psychosis
J Psychopharmacol, January 1, 1996; 10(1): 77 - 87.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1989 The Royal College of Psychiatrists.