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The British Journal of Psychiatry 155: 818-821 (1989)
© 1989 The Royal College of Psychiatrists
JA Besson, SG Greentree, MA Foster and JE Rimmington
Department of Mental Health, University of Aberdeen.
In rats, neither acute administration of ethanol nor the establishment of ethanol dependence by chronic administration for 28 days produced significant 1H-NMR relaxation changes. However, chronic ethanol intake for six months produced a transient rise in T1, with no change in T2 or water content. The significance of these results for study in man is discussed and a hypothesis is proposed to explain discrepant differences between T1, T2 and water content. It is suggested that T1 change with long-term ethanol exposure is related to altered free/bound water state secondary to cell membrane changes.
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