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The British Journal of Psychiatry 156: 635-644 (1990)
© 1990 The Royal College of Psychiatrists

Alcohol and the brain

WA Lishman
Institute of Psychiatry, Denmark Hill, London.

Some of the major effects of alcohol, and alcoholism, on the brain are reviewed, with reappraisal of evidence drawn from brain imaging, neuropathology, clinical psychology, and laboratory experimental work. A hypothesis is developed which may help to account for the wide variability encountered in individual susceptibility to alcoholic brain damage and its varied manifestations. Therapeutic implications are considered.


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