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The British Journal of Psychiatry 158: 278-280 (1991)
© 1991 The Royal College of Psychiatrists

Encephalopathy resembling Creutzfeldt-Jakob disease following oral, prescribed doses of bismuth nitrate

MJ Von Bose and M Zaudig
Max-Planck-Institute for Psychiatry, Munchen, Germany.

A patient given bismuth nitrate in the recommended dose range over 16 months developed panic attacks and a major depressive syndrome and, after 15 months, a myoclonic encephalopathy resembling Creutzfeldt- Jakob disease. He recovered four months after bismuth had been discontinued. Bismuth preparations are becoming popular in the treatment of gastritis; close attention to neurological and psychiatric symptoms seems mandatory.


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 Hum Exp ToxicolHome page
L. Noach, J. Eekhof, L. Bour, F. Posthumus Meyjes, G. Tytgat, and B. Ongerboer de Visser
Bismuth salts and neurotoxicity. A randomised, single-blind and controlled study
Human and Experimental Toxicology, April 1, 1995; 14(4): 349 - 355.
[Abstract] [PDF]


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Copyright © 1991 The Royal College of Psychiatrists.