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The British Journal of Psychiatry 158: 503-510 (1991)
© 1991 The Royal College of Psychiatrists
JA Lieberman, BL Saltz, CA Johns, S Pollack, M Borenstein and J Kane
Hillside Hospital, Glen Oaks, New York.
This article reviews eight published studies that describe clozapine's effects on TD and examines the outcome of 30 patients with TD treated with clozapine for up to 36 months. These data indicate that TD response to clozapine is variable but that approximately 43% of cases, particularly those with dystonic features, improved after clozapine treatment. Methodological limitations of the studies described, however, preclude definitive conclusions, which must await appropriately controlled trials.
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