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The British Journal of Psychiatry 158: 630-634 (1991)
© 1991 The Royal College of Psychiatrists

No genetic linkage detected for schizophrenia to Xq27-q28

LE Delisi, TJ Crow, KE Davies, JD Terwilliger, J Ott, R Ram, T Flint and A Boccio
Department of Psychiatry, Health Sciences Center, SUNY Stony Brook 11794.

The hypothesis that at least a subgroup of familial cases of schizophrenia could be due to a genetic defect on the X chromosome is supported by the observation of an excess of X-chromosome aneuploidies (XXX and XXY) among populations of patients with psychosis. The distal long arm, Xq27-q28, is a candidate region where linkage has been claimed to manic-depressive disorder and a fragile site has been associated with schizophrenia spectrum disorders. The present study excluded linkage to a large part of this region using four polymorphic probes and multipoint lod-score analysis in 10 families with multiple members with schizophrenia.




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1991 The Royal College of Psychiatrists.