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The British Journal of Psychiatry 158: 850-853 (1991)
© 1991 The Royal College of Psychiatrists

Is the predisposition to neuroleptic malignant syndrome genetically transmitted?

K Otani, M Horiuchi, T Kondo, S Kaneko and Y Fukushima
Department of Neuropsychiatry, Hirosaki University Hospital, Japan.

A Japanese family consisting of a mother and her two daughters, all experienced NMS on therapeutic or subtherapeutic doses of neuroleptics. The mother and the elder daughter had past histories of severe neuroleptic-induced extrapyramidal symptoms. The predisposition to this syndrome may be genetically transmitted. We suggest that neuroleptic treatment should be introduced with extreme caution to a patient with a family history of NMS.


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Copyright © 1991 The Royal College of Psychiatrists.