The British Journal of Psychiatry 159: 262-266 (1991)
© 1991 The Royal College of Psychiatrists
Neuroendocrine challenge studies in puerperal psychoses. Dexamethasone suppression and TRH stimulation
ES Paykel, AM del Campo, W White and R Horton
Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital.
Subjects admitted to hospital with post-partum psychoses were compared with
matched normal post-partum controls using two neuroendocrine challenge
tests: dexamethasone suppression of cortisol and TRH stimulation of TSH.
Post-dexamethasone cortisol levels were significantly elevated. There were
less-clear hints of blunting of TSH response. In the small samples there
was no obvious association of abnormalities with any particular diagnoses
within the range of mania, psychotic depression and schizoaffective
disorders.