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The British Journal of Psychiatry 159: 410-414 (1991)
© 1991 The Royal College of Psychiatrists

P300 and reaction-time measures in senile dementia of the Alzheimer type

PA Williams, GH Jones, M Briscoe, R Thomas and P Cronin
Department of Psychological Medicine, Whitchurch Hospital, Cardiff.

Auditory evoked potentials were recorded in a choice reaction-time task. This test paradigm elicited the attention-related P300 component and was used to study cognitive processing. Compared with age-matched controls, 17 patients with dementia of the Alzheimer type were shown to have significantly longer reaction times as well as delayed latencies of several components of the auditory evoked potentials. The fractional increase in the reaction times was much greater than that of the P300 peak latency. The latter is commonly accepted as an index of stimulus- evaluation time. These findings suggest a delay in both response selection and stimulus evaluation.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1991 The Royal College of Psychiatrists.