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The British Journal of Psychiatry 159: 510-514 (1991)
© 1991 The Royal College of Psychiatrists
MP Austin, FG Souza and GM Goodwin
Edinburgh University Department of Psychiatry, Royal Edinburgh Hospital.
A quantitative analysis was used to examine the efficacy of lithium augmentation in the acute treatment of depressed patients resistant to a standard trial of an antidepressant. Effect sizes were measured by the odds ratio using the Mantel-Haenszel method. Only controlled trials were included in order to minimise bias in method. A highly statistically significant effect for lithium augmentation was found, the pooled odds ratio being 0.146 and its 95% confidence interval 0.05- 0.44 (i.e. the odds of remaining ill are reduced by between 56% and 95% with the use of lithium treatment). While these results support the case for lithium augmentation in treatment-resistant depression, there remains considerable uncertainty over the duration of treatment necessary to see and sustain the treatment response.
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 C.J. Hawley, S. Ratnam, H.A. Pattinson, S.J. Quick, and D. Echlin Safety and tolerability of combined treatment with moclobemide and SSRIs: a preliminary study of 19 patients J Psychopharmacol, January 1, 1996; 10(3): 241 - 245. [Abstract] [PDF]
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T. Dinan Treatment approaches to therapy-resistant depression J Psychopharmacol, January 1, 1995; 9(2_suppl): 199 - 204. [Abstract] [PDF]
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M. Peet Commentary on 'The management of treatment-resistant affective disorder: clinical perspectives' J Psychopharmacol, January 1, 1992; 6(2): 160 - 161. [PDF]
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