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The British Journal of Psychiatry 172: 184-185 (1998)
© 1998 The Royal College of Psychiatrists

Polydactyly and psychosis. Five cases of co-occurrence

AG Cardno, KC Murphy, LA Jones, AM Cobb, J Gray, P McGuffin and MJ Owen
University of Wales College of Medicine, Cardiff.

BACKGROUND: Abnormalities presumed to occur during foetal life have been associated with schizophrenia. Polydactyly is a developmental abnormality but no previous association has been reported between polydactyly and functional psychotic illness. METHOD: Individuals with both polydactyly and a functional psychosis were ascertained during a study of familial schizophrenia. RESULTS: Five such individuals were ascertained in the course of assessing 234 individuals with familial psychosis, giving a rate of polydactyly in the sample of around 10 times the general population rate. CONCLUSIONS: This study provides preliminary evidence that polydactyly is over-represented in individuals with familial schizophrenia and related psychotic illnesses.




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Copyright © 1998 The Royal College of Psychiatrists.