BJP CPD Online e-learning site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holmes, C.
Right arrow Articles by Mann, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holmes, C.
Right arrow Articles by Mann, A.

The British Journal of Psychiatry 174: 45-50 (1999)
© 1999 The Royal College of Psychiatrists

Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies

C Holmes, N Cairns, P Lantos and A Mann
University of Southnampton, Thornhill Research Unit, Moorgreen Hospital, London.

BACKGROUND: Following the success of the NINCDS-ADRDA criteria for Alzheimer's disease, groups interested in vascular dementia and dementia with Lewy bodies have now adopted similar criteria. AIMS: To assess whether the validity of these criteria are influenced by the prevalence of mixed pathologies or by the prevalence rate. METHOD: A community based post-mortem study. RESULTS: Mixed pathologies were common (33.8%). The high specificities obtained for the CDLB and NINDS- AIREN criteria (1.00 and 0.95, respectively) were associated with low sensitivities (0.22 and 0.43, respectively). Low prevalence and the presence of mixed pathologies had a deleterious effect on positive predictive values. CONCLUSIONS: Current clinical diagnostic criteria are good at detecting pathology per se but not at detecting pure pathology. A large proportion of subjects from the general population fulfilling probable CDLB, probable NINCDS-ADRDA or probable NINDS-AIREN will have mixed pathologies.


This article has been cited by other articles:


Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
S. Wiederkehr, M. Simard, C. Fortin, and R. van Reekum
Comparability of the Clinical Diagnostic Criteria for Vascular Dementia: A Critical Review. Part I
J Neuropsychiatry Clin Neurosci, May 1, 2008; 20(2): 150 - 161.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. Zaccai, C. Brayne, I. McKeith, F. Matthews, P. G. Ince, and On behalf of the MRC Cognitive Function, Ageing Ne
Patterns and stages of {alpha}-synucleinopathy: Relevance in a population-based cohort
Neurology, March 25, 2008; 70(13): 1042 - 1048.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
D S KNOPMAN
Cerebrovascular disease and dementia
Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S121 - S127.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
K KANTARCI
1H Magnetic resonance spectroscopy in dementia
Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S146 - S152.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
N. L. Foster, J. L. Heidebrink, C. M. Clark, W. J. Jagust, S. E. Arnold, N. R. Barbas, C. S. DeCarli, R. Scott Turner, R. A. Koeppe, R. Higdon, et al.
FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease
Brain, October 1, 2007; 130(10): 2616 - 2635.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
Y. Inui, H. Toyama, Y. Manabe, T. Sato, M. Sarai, K. Kosaka, N. Iwata, and K. Katada
Evaluation of Probable or Possible Dementia with Lewy Bodies Using 123I-IMP Brain Perfusion SPECT, 123I-MIBG, and 99mTc-MIBI Myocardial SPECT
J. Nucl. Med., October 1, 2007; 48(10): 1641 - 1650.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
J. V. Bowler
Modern concept of vascular cognitive impairment
Br. Med. Bull., September 1, 2007; 83(1): 291 - 305.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J M Bradshaw, M Saling, V Anderson, M Hopwood, and A Brodtmann
Higher cortical deficits influence attentional processing in dementia with Lewy bodies, relative to patients with dementia of the Alzheimer's type and controls
J. Neurol. Neurosurg. Psychiatry, October 1, 2006; 77(10): 1129 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. B. Leverenz, M. A. Fishel, E. R. Peskind, T. J. Montine, D. Nochlin, E. Steinbart, M. A. Raskind, G. D. Schellenberg, T. D. Bird, and D. Tsuang
Lewy Body Pathology in Familial Alzheimer Disease: Evidence for Disease- and Mutation-Specific Pathologic Phenotype.
Arch Neurol, March 1, 2006; 63(3): 370 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Age AgeingHome page
J. Zaccai, C. McCracken, and C. Brayne
A systematic review of prevalence and incidence studies of dementia with Lewy bodies
Age Ageing, November 1, 2005; 34(6): 561 - 566.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
R Vandenberghe and J Tournoy
Cognitive aging and Alzheimer's disease
Postgrad. Med. J., June 1, 2005; 81(956): 343 - 352.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
C Holmes, C Ballard, D Lehmann, A D. Smith, H Beaumont, I N Day, M N. Khan, S Lovestone, M McCulley, C M Morris, et al.
Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation
J. Neurol. Neurosurg. Psychiatry, May 1, 2005; 76(5): 640 - 643.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. Kantarci, R. C. Petersen, B. F. Boeve, D. S. Knopman, D. F. Tang-Wai, P. C. O'Brien, S. D. Weigand, S. D. Edland, G. E. Smith, R. J. Ivnik, et al.
1H MR spectroscopy in common dementias
Neurology, October 26, 2004; 63(8): 1393 - 1398.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
P. Quadri, C. Fragiacomo, R. Pezzati, E. Zanda, G. Forloni, M. Tettamanti, and U. Lucca
Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia
Am. J. Clinical Nutrition, July 1, 2004; 80(1): 114 - 122.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
L. S. Schneider
Estrogen and Dementia: Insights From the Women's Health Initiative Memory Study
JAMA, June 23, 2004; 291(24): 3005 - 3007.
[Full Text] [PDF]

Home page
 AJGPHome page
D. W. Tsuang, L. DiGiacomo, and T. D. Bird
Familial Occurrence of Dementia With Lewy Bodies
Am J Geriatr Psychiatry, April 1, 2004; 12(2): 179 - 188.
[Abstract] [Full Text] [PDF]

Home page
 FocusHome page
M. Serby and S. C. Samuels
Diagnostic Criteria for Dementia With Lewy Bodies Reconsidered
Focus, April 1, 2004; 2(2): 309 - 313.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
D. H.S. Silverman
Brain 18F-FDG PET in the Diagnosis of Neurodegenerative Dementias: Comparison with Perfusion SPECT and with Clinical Evaluations Lacking Nuclear Imaging
J. Nucl. Med., April 1, 2004; 45(4): 594 - 607.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
T Rahkonen, U Eloniemi-Sulkava, S Rissanen, A Vatanen, P Viramo, and R Sulkava
Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or older
J. Neurol. Neurosurg. Psychiatry, June 1, 2003; 74(6): 720 - 724.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
D. J. Sahlas
Dementia With Lewy Bodies and the Neurobehavioral Decline of Mervyn Peake
Arch Neurol, June 1, 2003; 60(6): 889 - 892.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
D. S. Knopman, J. E. Parisi, B. F. Boeve, R. H. Cha, H. Apaydin, A. Salviati, S. D. Edland, and W. A. Rocca
Vascular Dementia in a Population-Based Autopsy Study
Arch Neurol, April 1, 2003; 60(4): 569 - 575.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
D. W. Tsuang, A. M. Dalan, C. J. Eugenio, P. Poorkaj, P. Limprasert, A. R. La Spada, E. J. Steinbart, T. D. Bird, and J. B. Leverenz
Familial Dementia With Lewy Bodies: A Clinical and Neuropathological Study of 2 Families
Arch Neurol, October 1, 2002; 59(10): 1622 - 1630.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
D Liolitsa, J Powell, and S Lovestone
Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease
J. Neurol. Neurosurg. Psychiatry, September 1, 2002; 73(3): 261 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
D. H.S. Silverman and G. W. Small
Prompt Identification of Alzheimer's Disease With Brain PET Imaging of a Woman With Multiple Previous Diagnoses of Other Neuropsychiatric Conditions
Am J Psychiatry, September 1, 2002; 159(9): 1482 - 1488.
[Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J Lindeboom, B Schmand, L Tulner, G Walstra, and C Jonker
Visual association test to detect early dementia of the Alzheimer type
J. Neurol. Neurosurg. Psychiatry, August 1, 2002; 73(2): 126 - 133.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
Z Walker, D C Costa, R W H Walker, K Shaw, S Gacinovic, T Stevens, G Livingston, P Ince, I G McKeith, and C L E Katona
Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligand
J. Neurol. Neurosurg. Psychiatry, August 1, 2002; 73(2): 134 - 140.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
M D Greicius, M D Geschwind, and B L Miller
Presenile dementia syndromes: an update on taxonomy and diagnosis
J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 691 - 700.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J.C. de la Torre
Alzheimer Disease as a Vascular Disorder: Nosological Evidence
Stroke, April 1, 2002; 33(4): 1152 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
O. T. Rutschmann, D. B. Matchar, D. Seidenwurm, D. H. S. Silverman, and G. W. Small
Usefulness of Positron Emission Tomography in Evaluating Dementia
JAMA, February 27, 2002; 287(8): 985 - 987.
[Full Text] [PDF]

Home page
 JNMHome page
D. H.S. Silverman, S. S. Gambhir, H.-W. C. Huang, J. Schwimmer, S. Kim, G. W. Small, J. Chodosh, J. Czernin, and M. E. Phelps
Evaluating Early Dementia With and Without Assessment of Regional Cerebral Metabolism by PET: A Comparison of Predicted Costs and Benefits
J. Nucl. Med., February 1, 2002; 43(2): 253 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
I. G. McKEITH
Dementia with Lewy bodies
The British Journal of Psychiatry, February 1, 2002; 180(2): 144 - 147.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. Padovani, L. Pastorino, B. Borroni, F. Colciaghi, L. Rozzini, R. Monastero, J. Perez, C. Pettenati, M. Mussi, G. Parrinello, et al.
Amyloid precursor protein in platelets: A peripheral marker for the diagnosis of sporadic AD
Neurology, December 26, 2001; 57(12): 2243 - 2248.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
C Holmes, H Smith, R Ganderton, M Arranz, D Collier, J Powell, and S Lovestone
Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation
J. Neurol. Neurosurg. Psychiatry, December 1, 2001; 71(6): 777 - 779.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
R. Stewart
NICE guidelines and the treatment of Alzheimer's disease: evidence-based medicine may be discriminatory
The British Journal of Psychiatry, October 1, 2001; 179(4): 367 - 367.
[Full Text] [PDF]

Home page
 AJGPHome page
M. Serby and S. C. Samuels
Diagnostic Criteria for Dementia With Lewy Bodies Reconsidered
Am J Geriatr Psychiatry, August 1, 2001; 9(3): 212 - 216.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. Petrovitch, L.R. White, G.W. Ross, S.C. Steinhorn, C.Y. Li, K.H. Masaki, D.G. Davis, J. Nelson, J. Hardman, J.D. Curb, et al.
Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study
Neurology, July 24, 2001; 57(2): 226 - 234.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
T. Polvikoski, R. Sulkava, L. Myllykangas, I.-L. Notkola, L. Niinisto, A. Verkkoniemi, K. Kainulainen, K. Kontula, J. Perez-Tur, J. Hardy, et al.
Prevalence of Alzheimer's disease in very elderly people: A prospective neuropathological study
Neurology, June 26, 2001; 56(12): 1690 - 1696.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
G B FRISONI
Structural imaging in the clinical diagnosis of Alzheimer's disease: problems and tools
J. Neurol. Neurosurg. Psychiatry, June 1, 2001; 70(6): 711 - 718.
[Full Text] [PDF]

Home page
 NeurologyHome page
D. S. Knopman, S. T. DeKosky, J. L. Cummings, H. Chui, J. Corey-Bloom, N. Relkin, G. W. Small, B. Miller, and J. C. Stevens
Practice parameter: Diagnosis of dementia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology
Neurology, May 8, 2001; 56(9): 1143 - 1153.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
D. Knopman
Cerebrospinal Fluid {beta}-Amyloid and Tau Proteins for the Diagnosis of Alzheimer Disease
Arch Neurol, March 1, 2001; 58(3): 349 - 350.
[Full Text] [PDF]

Home page
 NeurologyHome page
O.L. Lopez, J.T. Becker, W. Klunk, J. Saxton, R.L. Hamilton, D.I. Kaufer, R.A. Sweet, C. Cidis Meltzer, S. Wisniewski, M.I. Kamboh, et al.
Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades: I
Neurology, December 26, 2000; 55(12): 1854 - 1862.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
I. G. McKeith, C. G. Ballard, R. H. Perry, P. G. Ince, J. T. O'Brien, D. Neill, K. Lowery, E. Jaros, R. Barber, P. Thompson, et al.
Prospective validation of Consensus criteria for the diagnosis of dementia with Lewy bodies
Neurology, March 14, 2000; 54(5): 1050 - 1058.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. Lovestone
Diabetes and dementia
Neurology, December 1, 1999; 53(9): 1907 - 1907.
[Full Text]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J. M R Goulding, D. F Signorini, S. Chatterjee, J. A R Nicoll, J. Stewart, R. Morris, and G A. Lammie
Inverse relation between Braak stage and cerebrovascular pathology in Alzheimer predominant dementia
J. Neurol. Neurosurg. Psychiatry, November 1, 1999; 67(5): 654 - 657.
[Abstract] [Full Text]

Home page
 NeurologyHome page
I. G. McKeith, E. K. Perry, and R. H. Perry
Report of the second dementia with Lewy body international workshop: Diagnosis and treatment
Neurology, September 1, 1999; 53(5): 902 - 902.
[Abstract] [Full Text] [PDF]

Home page
 Evid. Based Ment. HealthHome page
S. Berman and H. J Bursztajn
Clinical criteria for three types of dementia had low sensitivity and high specificity
Evid. Based Ment. Health, August 1, 1999; 2(3): 91 - 91.
[Full Text]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
R Barber, P Scheltens, A Gholkar, C Ballard, I McKeith, P Ince, R Perry, and J O'Brien
White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging
J. Neurol. Neurosurg. Psychiatry, July 1, 1999; 67(1): 66 - 72.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1999 The Royal College of Psychiatrists.