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The British Journal of Psychiatry 174: 444-448 (1999)
© 1999 The Royal College of Psychiatrists

Changes in personality traits during treatment with sertraline or citalopram

L Ekselius and L Von Knorring
Department of Neuroscience, Psychiatry, University Hospital, Uppsala, Sweden.

BACKGROUND: Recent studies indicate that selective serotonin re-uptake inhibitors (SSRIs) reduce the symptoms accompanying personality disorders and modulate a normal personality. AIMS: To examine the effect of two SSRIs, sertraline and citalopram, on personality traits in major depressed patients. METHOD: Personality traits were evaluated at baseline and after six months using the Karolinska Scales of Personality (KSP). RESULTS: After treatment, significant changes in the direction of normalisation were seen in all scales. To determine whether the observed changes could be explained by improved depressive symptoms, multiple stepwise regressions with the separate KSP as dependent variables were performed. Improvements in depressive symptoms only accounted for 0-8.4% of the observed variance. CONCLUSIONS: In depressed patients treated with SSRIs significant effects are seen on personality traits measured by the KSP.


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D. J. Hellerstein, J. H. Kocsis, D. Chapman, J. W. Stewart, and W. Harrison
Double-Blind Comparison of Sertraline, Imipramine, and Placebo in the Treatment of Dysthymia: Effects on Personality
Am J Psychiatry, September 1, 2000; 157(9): 1436 - 1444.
[Abstract] [Full Text]


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Copyright © 1999 The Royal College of Psychiatrists.