| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Psychiatric Bulletin | Advances in Psychiatric Treatment | All RCPsych Journals |
|
|
|
||||||||||
|
||||||||||||
The British Journal of Psychiatry 175: 246-251 (1999)
© 1999 The Royal College of Psychiatrists
IN Ferrier, BR Stanton, TP Kelly and J Scott
Department of Psychiatry, University of Newcastle, Newcastle upon Tyne.
BACKGROUND: The assumption that patients with bipolar disorder make a full inter-episode recovery has been challenged by limited evidence that suggests that neuropsychological dysfunction in bipolar disorder may persist beyond episodes of illness. AIMS: To test the hypothesis that patients with euthymic bipolar disorder show neuropsychological impairment. METHOD: A battery of neuropsychological tests (assessed attention, working memory, learning and executive function) was administered to three matched groups of subjects: good-outcome patients with bipolar disorder (n = 21); poor-outcome patients with bipolar disorder (n = 20); controls (n = 20). All patients were clinically euthymic, although some had low levels of depressive symptoms. RESULTS: Patients performed worse than controls on a number of neuropsychological tests. When age, premorbid IQ and depressive symptoms were controlled for, the results indicated impairment of executive function. CONCLUSIONS: These findings provide good evidence for the existence of neuropsychological impairment in patients with euthymic bipolar disorder, although the possible effect of medication should not be overlooked. This may be of clinical relevance and raises questions about the course and outcome of the illness.
This article has been cited by other articles:
|
|
 |
|
  L. Altshuler, J. Tekell, K. Biswas, A. M. Kilbourne, D. Evans, D. Tang, and M. S. Bauer Executive Function and Employment Status Among Veterans With Bipolar Disorder Psychiatr Serv, November 1, 2007; 58(11): 1441 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Scott and M. J. Cleary A Patient With Bipolar Illness and Her Neuropsychological Signature Clinical Case Studies, October 1, 2007; 6(5): 412 - 429. [Abstract] [PDF]
|
|
|
|
 |
|
 U. S. KOLUR, Y.C.J. REDDY, J.P. JOHN, T. KANDAVEL, and S. JAIN Sustained attention and executive functions in euthymic young people with bipolar disorder The British Journal of Psychiatry, November 1, 2006; 189(5): 453 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Torrent, A. Martinez-Aran, C. Daban, J. Sanchez-Moreno, M. Comes, J. M. Goikolea, M. Salamero, and E. Vieta Cognitive impairment in bipolar II disorder The British Journal of Psychiatry, September 1, 2006; 189(3): 254 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. McAllister-Williams Relapse prevention in bipolar disorder: a critical review of current guidelines. J Psychopharmacol, March 1, 2006; 20(2 Suppl): 12 - 16. [Abstract] [PDF]
|
|
|
|
|
|
L. JONES, J. SCOTT, S. HAQUE, K. GORDON-SMITH, J. HERON, S. CAESAR, C. COOPER, L. FORTY, S. HYDE, L. LYON, et al. Cognitive style in bipolar disorder The British Journal of Psychiatry, November 1, 2005; 187(5): 431 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Varma Advance Directives for Persons With Serious Mental Illness Psychiatr Serv, July 1, 2005; 56(7): 874 - 875. [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. Cannon-Spoor, J. A. Levy, G. S. Zubenko, W. W. Zubenko, R. M. Cohen, N. Mirza, K. Putnam, and T. Sunderland Effects of Previous Major Depressive Illness on Cognition in Alzheimer Disease Patients Am J Geriatr Psychiatry, April 1, 2005; 13(4): 312 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Thompson, P. Gallagher, J. H. Hughes, S. Watson, J. M. Gray, I. N. Ferrier, and A. H. Young Neurocognitive impairment in euthymic patients with bipolar affective disorder The British Journal of Psychiatry, January 1, 2005; 186(1): 32 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L V Kessing and P K Andersen Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder? J. Neurol. Neurosurg. Psychiatry, December 1, 2004; 75(12): 1662 - 1666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Gildengers, M. A. Butters, K. Seligman, M. McShea, M. D. Miller, B. H. Mulsant, D. J. Kupfer, and C. F. Reynolds III Cognitive Functioning in Late-Life Bipolar Disorder Am J Psychiatry, April 1, 2004; 161(4): 736 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zammit, P. Allebeck, A. S. David, C. Dalman, T. Hemmingsson, I. Lundberg, and G. Lewis A Longitudinal Study of Premorbid IQ Score and Risk of Developing Schizophrenia, Bipolar Disorder, Severe Depression, and Other Nonaffective Psychoses Arch Gen Psychiatry, April 1, 2004; 61(4): 354 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Martinez-Aran, E. Vieta, M. Reinares, F. Colom, C. Torrent, J. Sanchez-Moreno, A. Benabarre, J. M. Goikolea, M. Comes, and M. Salamero Cognitive Function Across Manic or Hypomanic, Depressed, and Euthymic States in Bipolar Disorder Am J Psychiatry, February 1, 2004; 161(2): 262 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Surguladze, P. Keedwell, and M. Phillips Neural systems underlying affective disorders Advan. Psychiatr. Treat., November 1, 2003; 9(6): 446 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Harrison The neuropathology of primary mood disorder Brain, July 1, 2002; 125(7): 1428 - 1449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. N. FERRIER and J. M. THOMPSON Cognitive impairment in bipolar affective disorder: implications for the bipolar diathesis The British Journal of Psychiatry, April 1, 2002; 180(4): 293 - 295. [Full Text] [PDF]
|
|
|
|
|
|
L. CLARK, S. D. IVERSEN, and G. M. GOODWIN Sustained attention deficit in bipolar disorder The British Journal of Psychiatry, April 1, 2002; 180(4): 313 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.T.O. CAVANAGH, M. VAN BECK, W. MUIR, and D.H.R. BLACKWOOD Case--control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania The British Journal of Psychiatry, April 1, 2002; 180(4): 320 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. N. FERRIER, I. C. MacMILLAN, and A. H. YOUNG The search for the wandering thymostat: a review of some developments in bipolar disorder research The British Journal of Psychiatry, June 1, 2001; 178 (41): s103 - s106. [Full Text] [PDF]
|
|
|
|
|
|
F.C. MURPHY and B.J. SAHAKIAN Neuropsychology of bipolar disorder The British Journal of Psychiatry, June 1, 2001; 178 (41): s120 - s127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. McQUADE and A. H. Y. YOUNG Future therapeutic targets in mood disorders: the glucocorticoid receptor The British Journal of Psychiatry, November 1, 2000; 177(5): 390 - 395. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Psychiatric Bulletin | Advances in Psychiatric Treatment | All RCPsych Journals |
