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The British Journal of Psychiatry 175: 576-580 (1999)
© 1999 The Royal College of Psychiatrists
J Munro, D O'Sullivan, C Andrews, A Arana, A Mortimer and R Kerwin
Institute of Psychiatry, London.
BACKGROUND: People prescribed clozapine for treatment-resistant schizophrenia have mandatory haematological monitoring through a case register for identifying reversible neutropenia. AIMS: To quantify risk factors for agranulocytosis in subjects receiving clozapine. METHOD: Data from 12,760 subjects registered to receive clozapine from January 1990 to April 1997 were analysed. Risk factors for agranulocytosis were quantified using a Cox proportional-hazards regression analysis. RESULTS: The risk for agranulocytosis in Asian subjects was 2.4 times that in Caucasians (P = 0.03). There was an age-related increase in risk of 53% per decade (P = 0.0001). CONCLUSIONS: The case register yielded valuable information for guiding research into the causes of the haematological reactions.
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