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The British Journal of Psychiatry (2000) 176: 12-18
© 2000 The Royal College of Psychiatrists

Genetics advances and learning disability{dagger}

WALTER J. MUIR, MRCPsych

Department of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF

Declaration of interest None.

{dagger} See editorial pp. 10—11, this issue.

Background Medicine is rapidly becoming molecular medicine, and little escapes the grasp of modern genetics. Most disorders associated with learning disability have at least a genetic component influencing their expression; in many disorders, disturbances of genetic mechanisms play a pivotal role.

Aims Dynamic mutations, imprinting mechanisms and gene—dosage effects are explained with reference to genetic disorders that lead to learning disability.

Method A review of recent important studies in the genetics of learning disability.

Results A host of new genetic connections to conditions associated with learning disability have been made.

Conclusions A basic understanding of these genetic connections is important for all learning disability psychiatrists if they are to follow the rapid changes — already beginning to influence our practice — that hold immense promise for the future.




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