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Division of Neuroscience, Imperial College School of Medicine, Medical Research Council Cyclotron Unit, Hammersmith Hospital, London
Department of Psychiatry, University of British Columbia, Vancouver, Canada
Department of Psychological Medicine, Institute of Psychiatry, London
Department of Psychiatry and Behavioural Sciences, University of Manchester, Manchester
Wellcome Department of Cognitive Neurology, Institute of Neurology, London
Imperial College School of Medicine, Charing Cross Hospital, London
Department of Psychiatry and Behavioural Sciences, University of Manchester, Manchester
Correspondence: S. A. Spence, Functional Neuroimaging Laboratory, Department of Psychiatry, Box 171, New York Hospital — Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA. e-mail:sean{at}hanazono.med.cornell.edu
Declaration of interest No conflict of interest. Financial support detailed in Acknowledgements.
See invited commentary pp.
61—63, this issue.
Background PET studies of verbal fluency in schizophrenia report a failure of ‘deactivation’ of left superior temporal gyrus (STG) in the presence of activation of left dorsolateral prefrontal cortex (DLPFC), which deficit has been attributed to underlying ‘functional disconnectivity’.
Aim To test whether these findings provide trait-markers for schizophrenia.
Method We used H215O PET to examine verbal fluency in 10 obligate carriers of the predisposition to schizophrenia, 10 stable patients and 10 normal controls.
Results We found no evidence of a failure of left STG deactivation in carriers or patients. Instead, patients failed to deactivate the precuneus relative to other groups. We found no differences in functional connectivity between left DLPFC and left STG but patients exhibited significant disconnectivity between left DLPFC and anterior cingulate cortex.
Conclusions Failure of left STG ‘deactivation’ and left fronto-temporal disconnectivity are not consistent findings in schizophrenia; neither are they trait-markers for genetic risk. Prefrontal functional disconnectivity here may characterise the schizophrenic phenotype.
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