© 2000 The Royal College of Psychiatrists
Low blood pressure and risk of depression in the elderly
A prospective community-based study
Institut National de la Santé et de le Recherche Medicale, Hôpital Fernand Widal, Paris, France
Declaration of interest The project was partly funded by a grant from the Merck, Sharp and Dohme-Chibret Company and EISAI (France).
Correspondence: Dr Sabrina Paterniti, INSERM U360, Hôpital La Salpêtrière, 75651 Paris Cedex 13, France. Tel: 0083 1 42162554; Fax: 0033 1 42162541
Background The relationship between depression and low blood pressure is unclear.
Aims To examine the temporal relation between low blood pressure and depression in a two-year follow-up.
Method The study group consisted of 1389 subjects aged 59-71 years; 1272 (92%) were examined after two years. Subjects completed the Center for Epidemiological Studies—Depression (CES—D) and the Spielberger inventory scales to assess depressive and anxiety symptoms respectively. Data were collected on socio-demographic characteristics, smoking and drinking habits, medical history, drug use and blood pressure measures.
Results Among 1112 subjects who were considered as non-depressed at baseline, logistic regression models showed that low diastolic blood pressure (DBP) and decrease of blood pressure were predictors of high depressive symptomatology at follow-up. Baseline high CES—D scores did not predict low blood pressure two years after.
Conclusions In our study, low blood pressure was a risk factor for, but not a consequence of, high depressive symptomatology.
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