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Personality disorders and normal personality dimensions in obsessive—compulsive disorder

Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD

PAUL T. COSTA, Jr, PhD

Gerontology Research Center, National Institute on Aging, Baltimore, MD

MARK A. RIDDLE, MD

Department of Psychiatry and Behavioral Sciences and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD

KUNG-YEE LIANG, PhD

Department of Biostatistics, The Johns Hopkins School of Public Health, Baltimore, MD

RUDOLF HOEHN-SARIC, MD, MARCO A. GRADOS, MD and BERNADETTE A. M. CULLEN, BCh

Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Correspondence: Dr Jack Samuels, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins Hospital, Meyer 4-181, 600 N. Wolfe Street, Baltimore, MD 21287, USA

Declaration of interest Supported by National Institutes of Health grants R01MH50214 and NIH/NCRR/OPDGCRC RR00052.

Background Little is known about personality disorders and normal personality dimensions in relatives of patients with obsessive—compulsive disorder (OCD).

Aims To determine whether specific personality characteristics are part of a familial spectrum of OCD.

Method Clinicians evaluated personality disorders in 72 OCD case and 72 control probands and 198 case and 207 control first-degree relatives. The selfcompleted Revised NEO Personality Inventory was used for assessment of normal personality dimensions. The prevalence of personality disorders and scores on normal personality dimensions were compared between case and control probands and between case and control relatives.

Results Case probands and case relatives had a high prevalence of obsessive—compulsive personality disorder (OCPD) and high neuroticism scores. Neuroticism was associated with OCPD in case but not control relatives.

Conclusions Neuroticism and OCPD may share a common familial aetiology with OCD.

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