| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Psychiatric Bulletin | Advances in Psychiatric Treatment | All RCPsych Journals |
|
|
|
||||||||||
|
||||||||||||
University of Manchester School of Psychiatry and Behavioural Sciences
Correspondence: Dr Richard Drake, SOCRATES, University Department of Psychiatry, Withington Hospital, Manchester M20 8LR, UK
Declaration of interest Funded by the Medical Research Council and Stanley Foundation.
Background It is unclear what determines duration of untreated psychosis (DUP) in schizophrenia and why long DUP predicts poor outcome.
Aims First, to test the hypothesis that specific patterns of symptoms and social functioning acting before treatment prolong DUP. Second, to clarify the mechanisms linking DUP with recovery after treatment.
Method Two hundred and forty-eight consecutive first admissions with schizophrenia were interviewed to assess DUP, symptoms and social functioning at admission, and symptoms were re-assessed after 6-12 weeks.
Results Median DUP was 12 weeks. Long DUP was predicted by poor insight, social isolation and preserved coping skills, but not by demographic factors. Even allowing for all these variables, long DUP predicted poor outcome.
Conclusions Longer DUP results partly from a pattern of symptoms and social functioning which reduces concern by the sufferer and relevant others. DUP's relationship to outcome is strongest in the initial months of psychosis. This has implications for targeting early intervention.
This article has been cited by other articles:
|
|
 |
|
  R. L. Langlands, A. F. Jorm, C. M. Kelly, and B. A. Kitchener First Aid Recommendations for Psychosis: Using the Delphi Method to Gain Consensus Between Mental Health Consumers, Carers, and Clinicians Schizophr Bull, May 1, 2008; 34(3): 435 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Isaac, P. Chand, and P. Murthy Schizophrenia outcome measures in the wider international community The British Journal of Psychiatry, August 1, 2007; 191(50): s71 - s77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. MORGAN, R. ABDUL-AL, J. M. LAPPIN, P. JONES, P. FEARON, M. LEESE, T. CROUDACE, K. MORGAN, P. DAZZAN, T. CRAIG, et al. Clinical and social determinants of duration of untreated psychosis in the AeSOP first-episode psychosis study The British Journal of Psychiatry, November 1, 2006; 189(5): 446 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kisely, A. Scott, J. Denney, and G. Simon Duration of untreated symptoms in common mental disorders: association with outcomes: International study The British Journal of Psychiatry, July 1, 2006; 189(1): 79 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Edelsohn Hallucinations in Children and Adolescents: Considerations in the Emergency Setting Am J Psychiatry, May 1, 2006; 163(5): 781 - 785. [Full Text] [PDF]
|
|
|
|
|
|
G. HADDOCK, S. LEWIS, R. BENTALL, G. DUNN, R. DRAKE, and N. TARRIER Influence of age on outcome of psychological treatments in first-episode psychosis The British Journal of Psychiatry, March 1, 2006; 188(3): 250 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O. Perkins, H. Gu, K. Boteva, and J. A. Lieberman Relationship Between Duration of Untreated Psychosis and Outcome in First-Episode Schizophrenia: A Critical Review and Meta-Analysis Am J Psychiatry, October 1, 2005; 162(10): 1785 - 1804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Marshall, S. Lewis, A. Lockwood, R. Drake, P. Jones, and T. Croudace Association Between Duration of Untreated Psychosis and Outcome in Cohorts of First-Episode Patients: A Systematic Review Arch Gen Psychiatry, September 1, 2005; 62(9): 975 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M.G. NORMAN, S. W. LEWIS, and M. MARSHALL Duration of untreated psychosis and its relationship to clinical outcome The British Journal of Psychiatry, August 1, 2005; 187(48): s19 - s23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. O. JOHANNESSEN, T. K. LARSEN, I. JOA, I. MELLE, S. FRIIS, S. OPJORDSMOEN, B. R. RUND, E. SIMONSEN, P. VAGLUM, and T. H. McGLASHAN Pathways to care for first-episode psychosis in an early detection healthcare sector: Part of the Scandinavian TIPS study The British Journal of Psychiatry, August 1, 2005; 187(48): s24 - s28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. LEWIS, N. TARRIER, and R. J. DRAKE Integrating non-drug treatments in early schizophrenia The British Journal of Psychiatry, August 1, 2005; 187(48): s65 - s71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. WARNER Problems with early and very early intervention in psychosis The British Journal of Psychiatry, August 1, 2005; 187(48): s104 - s107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Baldwin, D. Browne, P. J Scully, J. F Quinn, M. G Morgan, A. Kinsella, J. M Owens, V. Russell, E. O'Callaghan, and J. L Waddington Epidemiology of First-Episode Psychosis: Illustrating the Challenges Across Diagnostic Boundaries Through the Cavan-Monaghan Study at 8 Years Schizophr Bull, July 1, 2005; 31(3): 624 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rosen and P. Garety Predicting Recovery From Schizophrenia: A Retrospective Comparison of Characteristics at Onset of People With Single and Multiple Episodes Schizophr Bull, July 1, 2005; 31(3): 735 - 750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-A. Chong, Mythily, A. Lum, Y. H. Chan, and P. McGorry Determinants of Duration of Untreated Psychosis and the Pathway to Care in Singapore International Journal of Social Psychiatry, March 1, 2005; 51(1): 55 - 62. [Abstract] [PDF]
|
|
|
|
 |
|
 T. K J Craig, P. Garety, P. Power, N. Rahaman, S. Colbert, M. Fornells-Ambrojo, and G. Dunn The Lambeth Early Onset (LEO) Team: randomised controlled trial of the effectiveness of specialised care for early psychosis BMJ, November 6, 2004; 329(7474): 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Shiers and H. Lester Early intervention for first episode psychosis BMJ, June 19, 2004; 328(7454): 1451 - 1452. [Full Text] [PDF]
|
|
|
|
|
|
I. Melle, T. K. Larsen, U. Haahr, S. Friis, J. O. Johannessen, S. Opjordsmoen, E. Simonsen, B. R. Rund, P. Vaglum, and T. McGlashan Reducing the Duration of Untreated First-Episode Psychosis: Effects on Clinical Presentation Arch Gen Psychiatry, February 1, 2004; 61(2): 143 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Ho, D. Alicata, J. Ward, D. J. Moser, D. S. O'Leary, S. Arndt, and N. C. Andreasen Untreated Initial Psychosis: Relation to Cognitive Deficits and Brain Morphology in First-Episode Schizophrenia Am J Psychiatry, January 1, 2003; 160(1): 142 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. SCULLY, J. F. QUINN, M. G. MORGAN, A. KINSELLA, E. O'CALLAGHAN, J. M. OWENS, and J. L. WADDINGTON First-episode schizophrenia, bipolar disorder and other psychoses in a rural Irish catchment area: incidence and gender in the Cavan--Monaghan study at 5 years The British Journal of Psychiatry, September 1, 2002; 181 (43): s3 - s9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. SKEATE, C. JACKSON, M. BIRCHWOOD, and C. JONES Duration of untreated psychosis and pathways to care in first-episode psychosis: Investigation of help-seeking behaviour in primary care The British Journal of Psychiatry, September 1, 2002; 181 (43): s73 - s77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. MORRISON, R. P. BENTALL, P. FRENCH, L. WALFORD, A. KILCOMMONS, A. KNIGHT, M. KREUTZ, and S. W. LEWIS Randomised controlled trial of early detection and cognitive therapy for preventing transition to psychosis in high-risk individuals: Study design and interim analysis of transition rate and psychological risk factors The British Journal of Psychiatry, September 1, 2002; 181 (43): s78 - s84. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V Seeman Poor insight, social avoidance, and better coping predicted prolonged duration of untreated psychosis in schizophreniaCommentary Evid. Based Ment. Health, May 1, 2001; 4(2): 57 - 57. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lewis and R. Drake Commentary Advan. Psychiatr. Treat., March 1, 2001; 7(2): 140 - 142. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Psychiatric Bulletin | Advances in Psychiatric Treatment | All RCPsych Journals |
