HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by HERRÁN, A. Articles by VÁZQUEZ-BARQUERO, J. L. Search for Related Content PubMed PubMed Citation Articles by HERRÁN, A. Articles by VÁZQUEZ-BARQUERO, J. L.

Effects of long-term treatment with antipsychotics on serum leptin levels

Clinical and Social Psychiatry Research Unit, Department of Psychiatry, University Hospital Marqués de Valdecilla, Santander, Spain

MARÍA TERESA GARCÍA-UNZUETA, MD and JOSÉ ANTONIO AMADO, MD

Department of Endocrinology, University Hospital Marqués de Valdecilla, Santander, Spain

MARÍA TERESA DE LA MAZA, MD and CONCEPCIÓN ÁLVAREZ, MD

Department of Biochemistry, University Hospital Marqués de Valdecilla, Santander, Spain

JOSÉ LUIS VÁZQUEZ-BARQUERO, FRCPsych

Clinical and Social Psychiatry Research Unit, Department of Psychiatry, University Hospital Marqués de Valdecilla, Santander, Spain

Correspondence: Andrés Herrán, Clinical and Social Psychiatry Research Unit, Department of Psychiatry, University Hospital Marqués de Valdecilla, Avda. de Valdecilla s/n, 39008 Santander, Spain. Tel: 34 942 202545; Fax: 34 942 203447; e-mail: herran{at}humv.es

Declaration of interest This study was supported by a grant from the Fundación Marqués de Valdecilla, 1996.

Background Abnormal regulation of the adipocyte-derived hormone leptin could play a role in body weight gain induced by antipsychotics.

Aims To study the effects of long-term antipsychotic treatment on leptin levels in patients with schizophrenia.

Method Serum leptin levels were determined in 59 out-patients with chronic schizophrenia and in the same number of healthy subjects controlled by gender, age and body mass index.

Results Leptin levels did not differ between patients and controls. Leptin levels in patients with schizophrenia correlated with weight gain, even after controlling for current weight, but did not show any association with clinical variables. Antipsychotic class tended to exert different effects over leptin levels (among atypicals, olanzapine induced a greater increase).

Conclusions Elevation of leptin levels induced by chronic antipsychotic treatment can be attributed to weight gain, but other mechanisms could be involved.

This article has been cited by other articles:

				O. Sentissi, J. Epelbaum, J.-P. Olie, and M.-F. Poirier Leptin and Ghrelin Levels in Patients With Schizophrenia During Different Antipsychotics Treatment: A Review Schizophr Bull, December 28, 2007; (2007) sbm141v1. [Abstract] [Full Text] [PDF]

				A. Sarandol, S. Kirli, C. Akkaya, N. Ocak, E. Eroz, and E. Sarandol Coronary artery disease risk factors in patients with schizophrenia: effects of short term antipsychotic treatment J Psychopharmacol, November 1, 2007; 21(8): 857 - 863. [Abstract] [PDF]

				J. R. Bola Psychosocial Acute Treatment in Early-Episode Schizophrenia Disorders Research on Social Work Practice, May 1, 2006; 16(3): 263 - 275. [Abstract] [PDF]

				H. Hosojima, T. Togo, T. Odawara, K. Hasegawa, S. Miura, Y. Kato, A. Kanai, A. Kase, H. Uchikado, and Y. Hirayasu Early effects of olanzapine on serum levels of ghrelin, adiponectin and leptin in patients with schizophrenia J Psychopharmacol, January 1, 2006; 20(1): 75 - 79. [Abstract] [PDF]

				V. J. Fedorowicz and E. Fombonne Metabolic side effects of atypical antipsychotics in children: a literature review J Psychopharmacol, September 1, 2005; 19(5): 533 - 550. [Abstract] [PDF]

				E K. Hester and M. R Thrower Current Options in the Management of Olanzapine-Associated Weight Gain Ann. Pharmacother., February 1, 2005; 39(2): 302 - 310. [Abstract] [Full Text] [PDF]

				D. C. Henderson, E. Cagliero, P. M. Copeland, C. P. Borba, E. Evins, D. Hayden, M. T. Weber, E. J. Anderson, D. B. Allison, T. B. Daley, et al. Glucose Metabolism in Patients With Schizophrenia Treated With Atypical Antipsychotic Agents: A Frequently Sampled Intravenous Glucose Tolerance Test and Minimal Model Analysis Arch Gen Psychiatry, January 1, 2005; 62(1): 19 - 28. [Abstract] [Full Text] [PDF]

				Z.-J. ZHANG, Z.-J. YAO, W. LIU, Q. FANG, and G. P. REYNOLDS Effects of antipsychotics on fat deposition and changes in leptin and insulin levels: Magnetic resonance imaging study of previously untreated people with schizophrenia The British Journal of Psychiatry, January 1, 2004; 184(1): 58 - 62. [Abstract] [Full Text] [PDF]

				F. M. Wurst, G. Bechtel, S. Forster, M. Wolfersdorf, P. Huber, A. Scholer, L. Pridzun, A. Alt, S. Seidl, J. Dierkes, et al. LEPTIN LEVELS OF ALCOHOL ABSTAINERS AND DETOXIFICATION PATIENTS ARE NOT DIFFERENT Alcohol Alcohol., July 1, 2003; 38(4): 364 - 368. [Abstract] [Full Text] [PDF]

				M. E.J. Lean and F.-G. Pajonk Patients on Atypical Antipsychotic Drugs: Another high-risk group for type 2 diabetes Diabetes Care, May 1, 2003; 26(5): 1597 - 1605. [Abstract] [Full Text] [PDF]

				T. Baptista and S. Beaulieu Leptin and antipsychotic drugs The British Journal of Psychiatry, December 1, 2001; 179(6): 560 - 561. [Full Text]